Hydrazine → HCID 178424851, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH2:10][C:11]#[N:12])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[NH2:14][NH2:15]>CCO>[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([NH2:12])[NH:14][N:15]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3-(3,5-Dimethyl-phenyl)-3-oxo-propionitrile (2.0175 gms.) is then suspended in 55 mL of anhydrous EtOH. This suspension is treated with 0.73 mL of anhydrous hydrazine and subsequently heated to refluxing temperature for 1 day. The reaction mixture is concentrated in vacuo. The residue is then triturated with isopropanol to precipitate out the 5-(3,5-dimethyl-phenyl)-2H-pyrazol-3-ylamine as a white solid.
Aufarbeitung
- temperaturesubsequently heated
- temperatureto refluxing temperature for 1 day
- concentrationThe reaction mixture is concentrated in vacuo
- customThe residue is then triturated with isopropanol
- customto precipitate out the 5-(3,5-dimethyl-phenyl)-2H-pyrazol-3-ylamine as a white solid
Quellen und Nachweise
- ORD-Eintrag
- ord-cecb03a6a8ca476aa1528ae9b2350064
- Quelldatensatz
- uspto-grants-2008_07
- Patentnummer
- US07393870B2
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