Hydrazine → HCID 178424850, Verbindung

HRID 746714Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 746714
O=[C:2]([CH2:6][C:7]1[CH:8]=[C:9]([CH3:13])[CH:10]=[CH:11][CH:12]=1)[CH2:3][C:4]#[N:5].[NH2:14][NH2:15]>CCO>[CH3:13][C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=1)[CH2:6][C:2]1[CH:3]=[C:4]([NH2:5])[NH:14][N:15]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 222416723-Oxo4-m-tolyl-butyronitrile

Produkt 1

HCID 178424850HCID 178424850, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3-Oxo-4-m-tolyl-butyronitrile (2.5583 gms.) is then suspended in 50 mL of anhydrous EtOH. This suspension is treated with 1.0 mL of anhydrous hydrazine, and subsequently heated to refluxing temperature for 1 day. The reaction mixture is concentrated in vacuo. The residue is then triturated with isopropanol to precipitate out the 5-(3-methyl-benzyl)-2H-pyrazol-3-ylamine.

Aufarbeitung

  1. temperaturesubsequently heated
  2. temperatureto refluxing temperature for 1 day
  3. concentrationThe reaction mixture is concentrated in vacuo
  4. customThe residue is then triturated with isopropanol
  5. customto precipitate out the 5-(3-methyl-benzyl)-2H-pyrazol-3-ylamine

Quellen und Nachweise

ORD-Eintrag
ord-5f7346172f9f43498b9962a2560fc0ba
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07393870B2

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