1-Carbethoxy-4-ethylamino-3-methylpiperidine → 4-Ethylamino-3-methylpiperidine

HRID 746853Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 746853
C([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][CH2:13][CH3:14])[CH:8]([CH3:15])[CH2:7]1)(OCC)=O>[OH-].[Na+]>[CH2:13]([NH:12][CH:9]1[CH2:10][CH2:11][NH:6][CH2:7][CH:8]1[CH3:15])[CH3:14]

Komponenten

3

Edukt 1

HCID 222789001-Carbethoxy-4-ethylamino-3-methylpiperidine

Produkt 1

HCID 222788594-Ethylamino-3-methylpiperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

1-Carbethoxy-4-ethylamino-3-methylpiperidine (2.3 g, 10.74 mmol) was suspended in 5 M NaOH solution (15 ml), stirred at 110° C. for 120 hr, cooled, extracted with ethyl acetate, dried (Na2SO4) and concentrated to dryness to afford 4-ethylamino-3-methylpiperidine. Yield 0.7 g (46%), C8H18N2, m/z 143, (M+1).

Aufarbeitung

  1. temperaturecooled
  2. extractionextracted with ethyl acetate
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-310b5414d9e94fc88d6398a0075074e0
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07393957B2

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