4-Amino-1-benzyl-3-ethyl-3-methylpiperidine → HCID 22278891, Verbindung

HRID 746884Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 746884
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5](CC2C=CC=CC=2)[CH2:4][C:3]1([CH2:16][CH3:17])[CH3:15]>CO.[H][H].[OH-].[OH-].[Pd+2]>[NH2:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][C:3]1([CH2:16][CH3:17])[CH3:15]

Komponenten

5

Edukt 1

HCID 222788954-Amino-1-benzyl-3-ethyl-3-methylpiperidine

Produkt 1

HCID 22278891HCID 22278891, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

A mixture of 20% Pd(OH)2 on carbon (0.2 g) and 4-amino-1-benzyl-3-ethyl-3-methylpiperidine (0.6 g, 2.58 mmol) in methanol (210 ml) was stirred in hydrogen atmosphere (1 atm.) at 30° C. for 6 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford 4-amino-3-ethyl-3-methylpiperidine. Yield 0.27 g (74%), C8H18N2, m/z 143 (M+1).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-06e446a9931f4f79b9201e88557b6771
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07393957B2

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