HCID 22278853, Verbindung → 4-Methylamino-3-ethyl-3-methylpiperidine

HRID 746886Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 746886
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][CH3:15])[C:10]([CH2:17][CH3:18])([CH3:16])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[OH-].[Pd+2]>[CH3:15][NH:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1([CH2:17][CH3:18])[CH3:16]

Komponenten

5

Edukt 1

HCID 22278853HCID 22278853, Verbindung

Produkt 1

HCID 222788634-Methylamino-3-ethyl-3-methylpiperidine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

A mixture of 20% Pd(OH)2 on carbon (0.7 g) and 1-benzyl-4-methylamino-3-ethyl-3-methyl piperidine (6 g, 24.39 mmol) in methanol (60 ml) was stirred in hydrogen atmosphere (1 atm.) at 60° C. for 6 hr. The catalyst was filtered off, washed with methanol and filtrate was concentrated to dryness to afford 4-methylamino-3-ethyl-3-methylpiperidine. Yield 2.5 g (66%), C9H20N2, m/z 157 (M+1).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-cca33a00f3b448b597cfef59936c122f
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07393957B2

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