HCID 22278860, Verbindung → 4-Dimethylamino-3-ethyl-3-methylpiperidine

HRID 746890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 746890
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:16])[CH3:15])[C:10]([CH2:18][CH3:19])([CH3:17])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[OH-].[Pd+2]>[CH3:15][N:14]([CH3:16])[CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1([CH2:18][CH3:19])[CH3:17]

Komponenten

5

Edukt 1

HCID 22278860HCID 22278860, Verbindung

Produkt 1

HCID 222788404-Dimethylamino-3-ethyl-3-methylpiperidine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

A mixture of 20% Pd(OH)2 on carbon (0.7 g) and 1-benzyl-4-dimethylamino-3-ethyl-3-methyl piperidine (6 g, 23 mmol) in methanol (50 ml) was stirred in hydrogen atmosphere (1 atm.) for 48 hr at room temperature. The catalyst was filtered off, washed with methanol and filtrate was concentrated to afford 4-dimethylamino-3-ethyl-3-methylpiperidine. Yield 2.8 g (72%), C10H22N2, m/z 171 (M+1).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated

Quellen und Nachweise

ORD-Eintrag
ord-4120684042c6486aaceb659f623574b5
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07393957B2

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