O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 58386737, Verbindung

HRID 74698Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 74698
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]3[N:20]=[CH:19][N:18]=[C:17]([C:21](O)=[O:22])[CH:16]=3)[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:24]=[CH:25][CH:26]=[CH:27][C:4]=2[NH:3]1.[NH:28]1[C:38]2[C:39]3[CH:30]([CH2:31][C:32](=[O:40])[NH:33][C:34]=3[CH:35]=[CH:36][CH:37]=2)[CH2:29]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C>[O:1]=[C:2]1[NH:3][C:4]2[CH:27]=[CH:26][CH:25]=[CH:24][C:5]=2[CH2:6][CH2:7][N:8]1[CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:20]=[CH:19][N:18]=[C:17]([C:21]([N:28]3[C:38]4[C:39]5[CH:30]([CH2:31][C:32](=[O:40])[NH:33][C:34]=5[CH:35]=[CH:36][CH:37]=4)[CH2:29]3)=[O:22])[CH:16]=2)[CH2:11][CH2:10]1

Komponenten

5

Edukt 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 104421921,2,2a,5-Tetrahydropyrrolo[4,3,2-de]quinolin-4(3H)-oneHCID 583864046-[4-(2-Oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid

Produkt 1

HCID 58386737HCID 58386737, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

63mg (0.17 mmol) 6-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid and 30 mg (0.17 mmol) 1,2,2a,5-tetrahydro-3H-pyrrolo-[4,3,2-de]quinolin-4-one in 56 μL (0.40 mmol) TEA and 1.8 mL DMF were mixed with 58 mg (0.18 mmol) TBTU and the mixture was stirred overnight at RT. Then the reaction mixture was purified by preparative HPLC-MS. The product-containing fractions were combined and freeze-dried.

Aufarbeitung

  1. customThen the reaction mixture was purified by preparative HPLC-MS
  2. customfreeze-dried

Quellen und Nachweise

ORD-Eintrag
ord-e3864c8e1a2644cf9abd6589fdc61f5f
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829006B2

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