Chloroacetic Acid → [(2-Propanylideneamino)oxy]acetic acid

HRID 747077Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 747077
[CH3:1][C:2](=[N:4][OH:5])[CH3:3].Cl[CH2:7][C:8]([OH:10])=[O:9].[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH3:1][C:2](=[N:4][O:5][CH2:7][C:8]([OH:10])=[O:9])[CH3:3]

Komponenten

6

Edukt 3

HCID 300Chloroacetic AcidHCID 14798Sodium HydroxideHCID 67180Acetone, oxime

Produkt 1

HCID 79344[(2-Propanylideneamino)oxy]acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 74236Tetrabutylammonium BromideKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

7.3 g of acetone oxime, 14.2 g of chloroacetic acid and 2% of tetrabutylammonium bromide are placed in 80 ml of toluene. An aqueous sodium hydroxide solution (10 g of sodium hydroxide dissolved in 150 ml of water) is added dropwise. The reaction medium is stirred for 1 h and then the toluene is evaporated under vacuum. The residue is then acidified with concentrated hydrochloric acid to pH 2.5, then washed with water and extracted twice with ethyl acetate. The organic phase is dried over sodium sulfate and the solvent is evaporated to give the expected product.

Aufarbeitung

  1. customthe toluene is evaporated under vacuum
  2. washwashed with water
  3. extractionextracted twice with ethyl acetate
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. customthe solvent is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-20988d9a1e434193b54ddb81c32a440b
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07396525B2

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