Hydrochloric Acid → HCID 22351003, Verbindung

HRID 747503Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 747503
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]([CH2:21][CH2:22][CH2:23][NH:24]C(=O)OC(C)(C)C)[C:11](=[N:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[S:12][CH:13]=2)=[CH:5][CH:4]=1.Cl>O1CCOCC1>[NH2:24][CH2:23][CH2:22][CH2:21][N:10]1[C:9]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[CH:13][S:12][C:11]1=[N:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22351001t-butyl 3-[4-(4-methoxyphenyl)-2-(phenylimino)thiazol-3(2H)-yl]propylcarbamate

Produkt 1

HCID 22351003HCID 22351003, VerbindungAusbeute 122,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of t-butyl 3-[4-(4-methoxyphenyl)-2-(phenylimino)-thiazol-3(2H)-yl]propylcarbamate (400 mg) and a 4N solution of hydrogen chloride in dioxane (8 ml) was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure, and to the residue was added diethyl ether. The insoluble salt was collected by filtration to give the title compound (379 mg) as hydrochloride.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. additionto the residue was added diethyl ether
  3. filtrationThe insoluble salt was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-692a4af97287428bb06cfaada5974a65
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07396842B2

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