Ethylenediamine → Ethyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate

HRID 747667

Reaktionsgleichung

Reaktionsgleichung von HRID 747667
Cl.C(O[C:5]([C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=1)=[NH:6])C.[CH2:18](N)[CH2:19][NH2:20]>C(O)C>[NH:20]1[CH2:19][CH2:18][N:6]=[C:5]1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][CH:17]=1

Komponenten

4

Edukt 2

HCID 3301EthylenediamineHCID 68830640Ethyl 4-ethoxycarbonimidoylbenzoate hydrochloride

Produkt 1

HCID 22709787Ethyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2.96 g (11.5 mmol) of ethyl 4-ethoxycarbonimidoylbenzoate hydrochloride and 690 mg (11.5 mmol) of ethylenediamine were stirred in 100 ml of ethanol at 60° C. for 4 hours. The solvent was evaporated. 1 N aqueous sodium hydroxide solution was added to the residue. After the extraction with dichloromethane followed by the washing with saturated Aqueous NaCl solution and drying over anhydrous magnesium sulfate, the solvent was evaporated to obtain the title compound.

Aufarbeitung

  1. customThe solvent was evaporated
  2. addition1 N aqueous sodium hydroxide solution was added to the residue
  3. extractionAfter the extraction with dichloromethane
  4. dry with materialdrying over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-cb7ec3e54e204604bbb02da5465f2b1c
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07396844B1

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