Hydrochloric Acid → Ethyl 4-(3-cyanophenoxy)-2-butenoate

HRID 747715Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 747715
Br[CH2:2]/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6].[OH:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Cl>CN(C)C=O>[C:14]([C:13]1[CH:12]=[C:11]([CH:18]=[CH:17][CH:16]=1)[O:10][CH2:2][CH:3]=[CH:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])#[N:15]

Komponenten

7

Edukt 5

HCID 313Hydrochloric AcidHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 133943-CyanophenolHCID 5373944Ethyl (E)-4-bromobut-2-enoate

Produkt 1

HCID 54098496Ethyl 4-(3-cyanophenoxy)-2-butenoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1 g (3.9 mmol) of ethyl 4-bromocrotonate, 465 mg (3.9 mmol) of 3-hydroxybenzonitrile, 539 mg (3.9 mmol) of potassium carbonate and 647 mg (3.9 mmol)) of potassium iodide were stirred in N,N-dimethylformamide at room temperature for 3 days. 1 N hydrochloric acid was added to the reaction liquid. After the extraction with ethyl acetate, the extract was washed with 1 N aqueous sodium hydroxide solution and saturated aqueous common salt solution, and dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the title compound.

Aufarbeitung

  1. extractionAfter the extraction with ethyl acetate
  2. washthe extract was washed with 1 N aqueous sodium hydroxide solution and saturated aqueous common salt solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-1e09a9720de24a10a2518ff677d1b241
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07396844B1

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