Potassium Iodide → HCID 68836373, Verbindung

HRID 747789Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 747789
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13]Cl)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[C:19]#[N:20].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>C[N-]C.C(OCC)(=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13][O:15][C:16]1[CH:23]=[CH:22][CH:21]=[C:18]([C:19]#[N:20])[CH:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

7

Edukt 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 133943-CyanophenolHCID 54012228tert-Butyl (2R)-2-(chloromethyl)pyrrolidine-1-carboxylate

Produkt 1

HCID 68836373HCID 68836373, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8857Ethyl AcetateLösungsmittelHCID 182180DimethylazanideLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

430 mg (2 mmol) of 1-t-butoxycarbonyl-(2R)-2-chloromethyl pyrrolidine was dissolved in 5 ml of dimethylamide, and 238 mg (2 mmol) of 3-hydroxy benzonitrile, 500 mg (3 mmol) of potassium iodide, and 414 mg (3 mmol) of potassium carbonate were added thereto and stirred at 90° C. for 3 days. The reaction mixture was treated in an ordinary manner with ethyl acetate as the extractant, and the resulting residue was purified by silica gel column chromatography to obtain the title compound.

Aufarbeitung

  1. customwas purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-5319edb120b142f98aa8b1fa45921010
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07396844B1

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