Methyl chloroformate → 4-Fluoro-2-methylphenyl Methoxyformate

HRID 7479

Reaktionsgleichung

Reaktionsgleichung von HRID 7479
Cl[C:2]([O:4][CH3:5])=[O:3].[F:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH3:14])[CH:8]=1>[OH-].[Na+]>[C:2](=[O:3])([O:4][CH3:5])[O:13][C:10]1[CH:11]=[CH:12][C:7]([F:6])=[CH:8][C:9]=1[CH3:14]

Komponenten

4

Edukt 2

HCID 6586Methyl chloroformateHCID 1362954-Fluoro-2-methylphenol

Produkt 1

HCID 106790444-Fluoro-2-methylphenyl MethoxyformateAusbeute 78,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

Methyl chloroformate (6.8 ml, 88 mmol) was added over 30 minutes to a solution of 4-fluoro-2-methylphenol (10 g, 79 mmol) in 6% aqueous sodium hydroxide solution at 0° C. The mixture was stirred for 2 hours, then extracted with ethyl acetate (100 ml). The ethyl acetate extract was washed with water (100 ml) and dried (MgSO4) and the solvent removed by evaporation to give 4-fluoro-2-methylphenyl methyl carbonate (11.4 g, 78%) as an oil.

Aufarbeitung

  1. extractionextracted with ethyl acetate (100 ml)
  2. extractionThe ethyl acetate extract
  3. washwas washed with water (100 ml)
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-3fadd27d35ed4579aa61b756ed318a83
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087602B2

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