Isobutyraldehyde → 1-[1-(4-Fluorophenyl)-1H-pyrazol-5-yl]-2-methylpropan-1-ol
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)=[CH:4][CH:3]=1.[CH:13](=[O:17])[CH:14]([CH3:16])[CH3:15]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([CH:13]([OH:17])[CH:14]([CH3:16])[CH3:15])=[CH:11][CH:10]=[N:9]2)=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
This compound was prepared from 1-(4-fluorophenyl)-1H-pyrazole and isobutyraldehyde using the method described in example 10B and isolated as an oil in 45% yield. 1H NMR (400 MHz, DMSO-d6) δ 7.61 (m, 1H), 7.57 (m, 2H), 7.37 (t, 2H, J=8.9 Hz), 6.41 (m, 1H), 5.41 (m, 1H), 4.13 (m, 1H), 1.85 (m, 1H), 0.87 (d, 3H, J=6.6 Hz), 0.61 (d, 3H, J=6.8 Hz).
Aufarbeitung
- customisolated as an oil in 45% yield