HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 2-(4-tert-Butoxycarbonylamino-2-pyridyl)-4H-1,3-benzothiazine-4-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Edukt | tert-Butyl (2-cyanopyridin-4-yl)carbamate | HCID 22939607 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 2-(4-tert-Butoxycarbonylamino-2-pyridyl)-4H-1,3-benzothiazine-4-one | HCID 22939388 | 49% |
Reaktionsschritte
A mixture of methyl thiosalicylate (0.61 g, 3.7 mmol), 4-tert-butoxycarbonylamino-2-cyanopyridine (0.80 g, 3.7 mmol), triethylamine (0.80 ml, 5.7 mmol) and toluene (2.0 ml) was refluxed for 9 hrs. After cooling, the precipitated crystals were collected by filtration and dried to give the titled compound (0.60 g, 49%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07399759B2 |
| Quelldatensatz | uspto-grants-2008_07 |
| ORD ID | ord-a69a8eff33154d8ba87bd21a3bad250a |
| Quellennotiz | uspto-grants-2008_07 |