Diisopropyl Ether → 2-(4-Amino-2-pyridyl)-4H-1,3-benzothiazine-4-one

HRID 748213Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 748213
C(OC([NH:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]2[S:16][C:17]3[CH:25]=[CH:24][CH:23]=[CH:22][C:18]=3[C:19](=[O:21])[N:20]=2)[CH:10]=1)=O)(C)(C)C.C(OC(C)C)(C)C>FC(F)(F)C(O)=O>[NH2:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]2[S:16][C:17]3[CH:25]=[CH:24][CH:23]=[CH:22][C:18]=3[C:19](=[O:21])[N:20]=2)[CH:10]=1

Komponenten

4

Edukt 2

HCID 7914Diisopropyl EtherHCID 229393882-(4-tert-Butoxycarbonylamino-2-pyridyl)-4H-1,3-benzothiazine-4-one

Produkt 1

HCID 597501802-(4-Amino-2-pyridyl)-4H-1,3-benzothiazine-4-oneAusbeute 152,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

2-(4-tert-Butoxycarbonylamino-2-pyridyl)-4H-1,3-benzothiazine-4-one (100 mg, 0.28 mmol) was dissolved in trifluoroacetic acid (2.5 ml) under ice cooling condition, and the mixture was stirred for 5 hrs. The reaction mixture was combined with diisopropyl ether to precipitate crystals, which were collected by filtration, washed with diethyl ether and dried to give the titled compound (109 mg, 60%).

Aufarbeitung

  1. customto precipitate crystals, which
  2. filtrationwere collected by filtration
  3. washwashed with diethyl ether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dd7945c48d7c4dafb1b574ad1190cdb8
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07399759B2

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