Trifluoroacetic acid → 3-[6-(7-Methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

HRID 748239Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 748239
[CH3:1][O:2][C:3]1[CH:28]=[CH:27][C:6]2[C:7](=[O:26])[N:8]=[C:9]([C:11]3[N:16]=[C:15]([CH2:17][CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[CH:14]=[CH:13][CH:12]=3)[S:10][C:5]=2[CH:4]=1.FC(F)(F)C(O)=O>>[CH3:1][O:2][C:3]1[CH:28]=[CH:27][C:6]2[C:7](=[O:26])[N:8]=[C:9]([C:11]3[N:16]=[C:15]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:14]=[CH:13][CH:12]=3)[S:10][C:5]=2[CH:4]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 22939580tert-Butyl 3-[6-(7-methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate

Produkt 1

HCID 597501523-[6-(7-Methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of tert-butyl 3-[6-(7-methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate (0.40 g, 1.0 mmol) obtained in Example 173 and trifluoroacetic acid (5.0 ml) was stirred at 0° C. for 2 hrs. The reaction mixture was concentrated under reduced pressure, combined with diisopropyl ether to give the crystals, which were collected by filtration and dried.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto give the crystals, which
  3. filtrationwere collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ab1b46ece9e947a493bd4a0d9fe126e9
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07399759B2

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