HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methanol → 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy)-7-methoxyquinazolin-4(3H)-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methanol | HCID 887 | — |
| Edukt | 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy}-7-fluoroquinazolin-4(3H)-one | HCID 136351952 | — |
| Produkt | 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy)-7-methoxyquinazolin-4(3H)-one | HCID 136351955 | 63,1% |
Reaktionsschritte
An analogous reaction to that described in example 137b, but starting with 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy}-7-fluoroquinazolin-4(3H)-one (363 mg, 1 mmol) and methanol (162 μl, 4 mmol) at 110° C. for 2 hours yielded 5-{[1-(2-tert-butoxyethyl)piperidin-4-yl]oxy}-7-methoxyquinazolin-4(3H)-one (237 mg, 63% yield):
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07402585B2 |
| Quelldatensatz | uspto-grants-2008_07 |
| ORD ID | ord-5996ba45bb384c08a9574e4811c5099f |
| Quellennotiz | uspto-grants-2008_07 |