Oxirane, 2-propyl- → 1-(4-Methanesulfonylbenzylamino)pentan-2-ol

HRID 750121

Reaktionsgleichung

Reaktionsgleichung von HRID 750121
[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[O:13]1[CH:15]([CH2:16][CH2:17][CH3:18])[CH2:14]1>CO>[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH:10][CH2:14][CH:15]([OH:13])[CH2:16][CH2:17][CH3:18])=[CH:7][CH:6]=1)(=[O:3])=[O:4]

Komponenten

4

Edukt 2

HCID 13853Oxirane, 2-propyl-HCID 574214-Methylsulfonylbenzylamine

Produkt 1

HCID 230607521-(4-Methanesulfonylbenzylamino)pentan-2-olAusbeute 34,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution (50 ml) of 4-methanesulfonylbenzylamine (5.0 g) and 1,2-epoxypentane (2.8 g) in methanol was stirred at room temperature for 96 hrs. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=10:1) to give the title compound (2.5 g).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe obtained residue was purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=10:1)

Quellen und Nachweise

ORD-Eintrag
ord-2c44bf5e738b40f29830c347e2fc684b
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07402595B2

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