1,4-Dioxane hydrochloride → 6-carbamoyl-2-(4-carboxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

HRID 750257Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 750257
O1CCOCC1.Cl.[CH3:8][O:9][C:10]([C:12]1[N:13]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([C:39]([O:41]C(C)(C)C)=[O:40])=[CH:35][CH:34]=2)[C:14](=[O:31])[C:15]2[C:20]([C:21]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[CH:19][C:18]([C:28](=[O:30])[NH2:29])=[CH:17][CH:16]=2)=[O:11]>>[CH3:8][O:9][C:10]([C:12]1[N:13]([CH2:32][C:33]2[CH:34]=[CH:35][C:36]([C:39]([OH:41])=[O:40])=[CH:37][CH:38]=2)[C:14](=[O:31])[C:15]2[C:20]([C:21]=1[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[CH:19][C:18]([C:28](=[O:30])[NH2:29])=[CH:17][CH:16]=2)=[O:11]

Komponenten

3

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 691570372-(4-tert-butoxycarbonylbenzyl)-6-carbamoyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

Produkt 1

HCID 691567496-carbamoyl-2-(4-carboxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl EsterAusbeute 69 %

Versuchsvorschrift

To a 4N-hydrochloric acid dioxane solution (5 ml) was added 2-(4-tert-butoxycarbonylbenzyl)-6-carbamoyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (140 mg), and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was concentrated under reduced pressure, and the obtained crystals were washed with methanol to give the title compound (86 mg).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washthe obtained crystals were washed with methanol

Quellen und Nachweise

ORD-Eintrag
ord-d49cd52b741947b0b91ed9626f7ae955
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07402595B2

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