Mafenide Hydrochloride → 6-bromo-1-oxo-4-phenyl-2-(4-sulfamoylbenzyl)-1,2-dihydroisoquinoline-3-carboxylic Acid

HRID 750321

Reaktionsgleichung

Reaktionsgleichung von HRID 750321
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=O)[O:7][C:6]([C:13]([OH:15])=[O:14])=[C:5]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.Cl.[S:23]([C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH2:32])=[CH:29][CH:28]=1)(=[O:26])(=[O:25])[NH2:24]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:7])[N:32]([CH2:31][C:30]1[CH:29]=[CH:28][C:27]([S:23](=[O:25])(=[O:26])[NH2:24])=[CH:34][CH:33]=1)[C:6]([C:13]([OH:15])=[O:14])=[C:5]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Komponenten

3

Edukt 2

HCID 67313Mafenide HydrochlorideHCID 230607776-Bromo-4-phenyl-3-isocoumarincarboxylic acid

Produkt 1

HCID 230608246-bromo-1-oxo-4-phenyl-2-(4-sulfamoylbenzyl)-1,2-dihydroisoquinoline-3-carboxylic AcidAusbeute 71 %

Versuchsvorschrift

The title compound (3.64 g, 71%) was synthesized by a method similar to that in Example 331 and using 6-bromo-1-oxo-4-phenyl-1H-isochromen-3-carboxylic acid and 4-sulfamoylbenzylamine hydrochloride.

Quellen und Nachweise

ORD-Eintrag
ord-f36f6eac03fa414c899a8047cfb26c6f
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07402595B2

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