1-Amino-5-isopropylamino-pentan-3-ol → 5-[3-(3-Hydroxy-5-isopropylamino-pentyl)-ureido]-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazole-4-carboxylic acid amide

HRID 750605

Reaktionsgleichung

Reaktionsgleichung von HRID 750605
C1(O[C:8](=[O:30])[NH:9][C:10]2[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]3[C:22]([F:23])=[CH:21][C:20]([CH3:24])=[C:19]([F:25])[C:18]=3[F:26])[C:11]=2[C:27](=[O:29])[NH2:28])C=CC=CC=1.[NH2:31][CH2:32][CH2:33][CH:34]([OH:41])[CH2:35][CH2:36][NH:37][CH:38]([CH3:40])[CH3:39]>>[OH:41][CH:34]([CH2:35][CH2:36][NH:37][CH:38]([CH3:40])[CH3:39])[CH2:33][CH2:32][NH:31][C:8](=[O:30])[NH:9][C:10]1[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]2[C:22]([F:23])=[CH:21][C:20]([CH3:24])=[C:19]([F:25])[C:18]=2[F:26])[C:11]=1[C:27]([NH2:28])=[O:29]

Komponenten

3

Edukt 2

HCID 185507511-Amino-5-isopropylamino-pentan-3-olHCID 54053016[4-Carbamoyl-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester

Produkt 1

HCID 104361355-[3-(3-Hydroxy-5-isopropylamino-pentyl)-ureido]-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazole-4-carboxylic acid amide

Versuchsvorschrift

The title compound was prepared from [4-carbamoyl-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester and 1-amino-5-isopropylamino-pentan-3-ol by the procedure analogous to Example 1. MS (APCl, m/z): 504 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-777de53a873749d680e98bfa063d72f9
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07405218B2

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