Diethyl (1-cyanoethyl)phosphonate → (S)-N-{3-[4-(4-(1-cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Diethyl (1-cyanoethyl)phosphonate	HCID 282103	—
Edukt	(S)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine	HCID 69315308	—
Produkt	(S)-N-{3-[4-(4-(1-cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine	HCID 69315435	74%

Reaktionsschritte

The compound was prepared by following the procedure of Example-1 and by using (S)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine and diethyl-(1-cyanoethyl)-phosphonate in 74% yield.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07405228B2
Quelldatensatz	uspto-grants-2008_07
ORD ID	ord-6f684710c0a748bfb0eae79346601052
Quellennotiz	uspto-grants-2008_07