Diethyl (1-cyanoethyl)phosphonate → (R)-{3-[4-(4-(1-Cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Diethyl (1-cyanoethyl)phosphonate	HCID 282103	—
Edukt	(R)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol	HCID 60133490	—
Produkt	(R)-{3-[4-(4-(1-Cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol	HCID 69315198	63%

Reaktionsschritte

The title compound was prepared by following the procedure of Example 1 and by using (R)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol and diethyl(1-cyanoethyl)-phosphonate in 63% yield.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07405228B2
Quelldatensatz	uspto-grants-2008_07
ORD ID	ord-0bf5f29d86d548618b0491e97e281474
Quellennotiz	uspto-grants-2008_07