HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Iodide → [rac]-2-{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl]-propionic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Iodide | HCID 4875 | — |
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | Methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester | HCID 11616756 | — |
| Edukt | [Rac]-2-(6-hydroxy-indol-1-yl)-propionic acid ethyl ester | HCID 68826438 | — |
| Produkt | [rac]-2-{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl]-propionic acid ethyl ester | HCID 68824015 | — |
Reaktionsschritte
In analogy to the procedure described in example 11 c], [rac]-2-(6-hydroxy-indol-1-yl)-propionic acid ethyl ester (GB 2253848 A1) was reacted with methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester (example 9 a]) in the presence of cesium carbonate and potassium iodide to give the title compound as colorless liquid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07405236B2 |
| Quelldatensatz | uspto-grants-2008_07 |
| ORD ID | ord-244fb64dfeee4a8aa06781a10a19884e |
| Quellennotiz | uspto-grants-2008_07 |