Pyridine → Darinaparsin

HRID 751477Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 751477
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].[CH3:21][As:22]([CH3:24])Cl.N1C=CC=CC=1>COCCOC>[CH3:21][As:22]([CH3:24])[S:13][CH2:12][C@@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[NH:10][C:8](=[O:9])[CH2:7][CH2:6][C@@H:2]([C:3]([OH:5])=[O:4])[NH2:1]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 11200ChlorodimethylarsineHCID 124886Glutathione

Produkt 1

HCID 11683005Darinaparsin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

In a 500 mL flask, 7 g of glutathione was used as received from the Aldrich Chemical Co., purity 98% and dissolved in 250 mL of 1,2-dimethoxyethane. To this solution was added 3.3 g of dimethylchloroarsine. This was followed by the addition of 3.5 g of pyridine (redistilled after drying over NaOH pellets). The solution was refluxed for one hour after which time it was stirred at room temperature for three hours.

Aufarbeitung

  1. temperatureThe solution was refluxed for one hour after which time it

Quellen und Nachweise

ORD-Eintrag
ord-1d2d7a40ffad4f6f89dc233d9c543997
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07405314B2

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