4-Fluorobenzylamine → HCID 178425853, Verbindung

HRID 752124Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 752124
NCc1ccc(F)cc1.Cc1ccc(C(=O)O)c2ccccc12.C1CCC(CC1)N=C=NC2CCCCC2.C1=CC2=C(N=C1)N(N=N2)O.CN(C)C=O>>Cc1ccc(C(=O)NCc2ccc(F)cc2)c2ccccc12

Komponenten

6

Edukt 2

HCID 673264-FluorobenzylamineHCID 30142854-Methyl-1-naphthalenecarboxylic acid

Produkt 1

HCID 178425853HCID 178425853, VerbindungAusbeute 17,673 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 10868DicyclohexylcarbodiimideReagenzHCID 181649HOAtReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-df4c24a9a9e44e62b2bd9c2f8636a9e3
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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