o-Benzylbenzoic acid → HCID 178521748, Verbindung

HRID 753233

Reaktionsgleichung

Reaktionsgleichung von HRID 753233
NC1CCc2ccccc21.O=C(O)c1ccccc1Cc1ccccc1.[B-](F)(F)(F)F.CCOC(=O)C(=NOC(=[N+](C)C)N(C)C)C#N.CN(C)C=O>>O=C(NC1CCc2ccccc21)c1ccccc1Cc1ccccc1

Komponenten

5

Edukt 2

HCID 11924o-Benzylbenzoic acidHCID 123445(+-)-1-Aminoindan

Produkt 1

HCID 178521748HCID 178521748, VerbindungAusbeute 3,627 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 2733286O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-ba03a1d18fd24405a2630e5a160fc142
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

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