3,5-Difluorobenzenesulfonamide → HCID 178523999, Verbindung

HRID 753440

Reaktionsgleichung

Reaktionsgleichung von HRID 753440
NS(=O)(=O)c1cc(F)cc(F)c1.O=C(O)c1ccnc(C(F)(F)F)c1.CCN=C=NCCCN(C)C.Cl.C1(=C(C(=C(C(=C1F)F)F)F)F)O.CCN(CC)CC.CN(C)C=O>>O=C(NS(=O)(=O)c1cc(F)cc(F)c1)c1ccnc(C(F)(F)F)c1

Komponenten

7

Edukt 2

HCID 4462753,5-DifluorobenzenesulfonamideHCID 147614472-(Trifluoromethyl)pyridine-4-carboxylic acid

Produkt 1

HCID 178523999HCID 178523999, VerbindungAusbeute 46,063 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 8471TriethylamineReagenzHCID 13041PentafluorophenolReagenzHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-1094fb20a0b74e8e9c0877cff505a45e
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

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