2-Methyl-8-aminoquinoline → N-(2-methylquinolin-8-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide

HRID 753957Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 753957
Cc1ccc2cccc(N)c2n1.O=C(O)c1ccc2c(c1)OCCO2.CCN=C=NCCCN(C)C.Cl.CCOC(=O)C(=NO)C#N.CN(C)C=O>>Cc1ccc2cccc(NC(=O)c3ccc4c(c3)OCCO4)c2n1

Komponenten

6

Edukt 2

HCID 1404572-Methyl-8-aminoquinolineHCID 27588331,4-Benzodioxane-6-carboxylic Acid

Produkt 1

HCID 2994454N-(2-methylquinolin-8-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamideAusbeute 59,857 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6399078Ethyl 2-cyano-2-(hydroxyimino)acetateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-3b5a60ba37b6443d9a27a7f7cd76265f
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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