Cyclobutanecarbonyl chloride → N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclobutanecarboxamide

HRID 7543

Reaktionsgleichung

Reaktionsgleichung von HRID 7543
[NH2:1][CH:2]([C:5]1[C:6](=[O:16])[NH:7][C:8]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:9][N:10]=1)[CH2:3][CH3:4].[CH:17]1([C:21](Cl)=[O:22])[CH2:20][CH2:19][CH2:18]1>>[CH:11]1([C:8]2[NH:7][C:6](=[O:16])[C:5]([CH:2]([NH:1][C:21]([CH:17]3[CH2:20][CH2:19][CH2:18]3)=[O:22])[CH2:3][CH3:4])=[N:10][N:9]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

Komponenten

3

Edukt 2

HCID 78705Cyclobutanecarbonyl chlorideHCID 1355940676-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one

Produkt 1

HCID 135752666N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclobutanecarboxamide

Versuchsvorschrift

In analogy to the procedure for Example 36A, 200 mg (0.90 mmol) 6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one, 110 mg (0.90 mmol) cyclobutanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Aufarbeitung

  1. customThe crude product is used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-4bcafa10a53542d891597c168d3e248e
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087605B2

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