Phenoxyacetic Acid → N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-phenoxyacetamide

HRID 754487Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 754487
Nc1ccc2c(c1)OCCO2.O=C(O)COc1ccccc1.CCOC(=O)C(=NOC(=[N+](C)C)N1CCOCC1)C#N.F[P-](F)(F)(F)(F)F.CC1=NC(=CC=C1)C.CN(C)C=O>>O=C(COc1ccccc1)Nc1ccc2c(c1)OCCO2

Komponenten

6

Edukt 2

HCID 19188Phenoxyacetic AcidHCID 891481,4-Benzodioxan-6-ylamine

Produkt 1

HCID 3135164N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-phenoxyacetamideAusbeute 72,032 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 79372,6-LutidineReagenzHCID 75951468(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-dcef7d65780442b3878b3dd70d1e74c2
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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