Hexamethyldisilazane → Ethyl 1-cyclopentyl-2,5-dimethyl-1H-imidazole-4-carboxylate
Reaktionsgleichung
S([O-])([O-])(=O)=O.[NH4+].[NH4+].[C:8]([NH:11]/[C:12](=[C:18](/[NH:20][CH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1)\[CH3:19])/[C:13]([O:15][CH2:16][CH3:17])=[O:14])(=O)[CH3:9].C[Si](C)(C)N[Si](C)(C)C>>[CH:21]1([N:20]2[C:18]([CH3:19])=[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:11]=[C:8]2[CH3:9])[CH2:25][CH2:24][CH2:23][CH2:22]1Komponenten
4
Reaktionsbedingungen
- Temperatur
- 150 °C
Versuchsvorschrift
Ammonium sulfate (100 mg) was added to a solution of (E)-ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate (compound 18, 1.5 g, 5.9 mmol) and hexamethyldisilazane (15 mL) and refluxed overnight at 150° C. The reaction mixture was evaporated and extracted with EA and water. The organic layer was evaporated and the residue was purified with 20% methanol in CH2Cl2 to produce as a light brown solid (1.0 g, 71.4% yield).