Bicyclo(2.2.1)hept-5-ene-2-carbonyl chloride → N-[1-(3-Cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]bicyclo[2.2.1]hept-5-ene-2-carboxamide

HRID 7554

Reaktionsgleichung

Reaktionsgleichung von HRID 7554
[NH2:1][CH:2]([C:5]1[C:6](=[O:16])[NH:7][C:8]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:9][N:10]=1)[CH2:3][CH3:4].[CH:17]12[CH2:23][CH:20]([CH:21]=[CH:22]1)[CH2:19][CH:18]2[C:24](Cl)=[O:25]>>[CH:11]1([C:8]2[NH:7][C:6](=[O:16])[C:5]([CH:2]([NH:1][C:24]([CH:18]3[CH2:19][CH:20]4[CH2:23][CH:17]3[CH:22]=[CH:21]4)=[O:25])[CH2:3][CH3:4])=[N:10][N:9]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

Komponenten

3

Edukt 2

HCID 98233Bicyclo(2.2.1)hept-5-ene-2-carbonyl chlorideHCID 1355940676-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one

Produkt 1

HCID 135752647N-[1-(3-Cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]bicyclo[2.2.1]hept-5-ene-2-carboxamide

Versuchsvorschrift

In analogy to the procedure for Example 36A, 150 mg (0.67 mmol) 6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one, 120 mg (0.74 mmol) bicyclo[2.2.1]hept-5-ene-2-carbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Aufarbeitung

  1. customThe crude product is used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-f76a8a8b48e24cfcac66d166cb5a1dec
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087605B2

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