Isothiocyanatotrimethylsilane → Ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

Temperatur

110 °C

To a solution of (Z)-methyl 3-(2,4-dimethoxyphenyl)-3-((2-ethoxy-2-oxoethyl)amino)acrylate (4.68 g, 15.1 mmol) in 2-methyltetrahydrofuran (38 mL) was added (trimethylsilyl)isothiocyanate (12.9 mL, 90.8 mmol). The resulting solution was purged with nitrogen gas for 3 times, and the mixture was heated at 110° C. for 18 hours. The mixture was cooled down to room temperature and the solvent was removed under reduced pressure to give a red solid. This residue was suspended in a mixture of 3:1 heptane/EtOAc (200 mL), and it was stirred at room temperature for 1 hour. The solid was filtered, and triturated with CH2Cl2 (100 mL), concentrated under reduced pressure and dried under vacuum the title compound (4.42 g, 87%) as a pink solid. This material was used without further purification in the next step.

1. customThe resulting solution was purged with nitrogen gas for 3 times
2. temperatureThe mixture was cooled down to room temperature
3. customthe solvent was removed under reduced pressure
4. customto give a red solid
5. filtrationThe solid was filtered
6. customtriturated with CH2Cl2 (100 mL)
7. concentrationconcentrated under reduced pressure
8. dry with materialdried under vacuum the title compound (4.42 g, 87%) as a pink solid
9. customThis material was used without further purification in the next step

ORD-Eintrag

ord-5356724165aa47ea97f6a12f0ced82f0

Quelldatensatz

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08835449B2