Cyclohexaneacetic acid → 2-Cyclohexyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]acetamide

HRID 7562

Reaktionsgleichung

Reaktionsgleichung von HRID 7562
[NH2:1][CH:2]([C:5]1[C:6](=[O:16])[NH:7][C:8]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:9][N:10]=1)[CH2:3][CH3:4].[CH:17]1([CH2:23][C:24](O)=[O:25])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH:17]1([CH2:23][C:24]([NH:1][CH:2]([C:5]2[C:6](=[O:16])[NH:7][C:8]([CH:11]3[CH2:15][CH2:14][CH2:13][CH2:12]3)=[N:9][N:10]=2)[CH2:3][CH3:4])=[O:25])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Komponenten

3

Edukt 2

HCID 21363Cyclohexaneacetic acidHCID 1355940676-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one

Produkt 1

HCID 1357525262-Cyclohexyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]acetamide

Versuchsvorschrift

In analogy to the procedure for Example 58A, 150 mg (0.67 mmol) 6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one, 96 mg (0.67 mmol) cyclo-hexylacetic acid and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Aufarbeitung

  1. customThe crude product is used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-5df41889bf2647ffb1b74693fb65d127
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087605B2

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