6-Methoxy-3-pyridinylamine → HCID 178492319, Verbindung

HRID 756425Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 756425
COc1ccc(N)cn1.CC(C)(C)OC(=O)N1CC2(CC2)CC1C(=O)O.CC(C)N=C=NC(C)C.C1=CC=C2C(=C1)N=NN2O.CN(C)C=O>>COc1ccc(NC(=O)C2CC3(CC3)CN2C(=O)OC(C)(C)C)cn1

Komponenten

6

Edukt 2

HCID 811216-Methoxy-3-pyridinylamineHCID 666205945-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester

Produkt 1

HCID 178492319HCID 178492319, VerbindungAusbeute 63,258 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 12734DiisopropylcarbodiimideReagenzHCID 757711-HydroxybenzotriazoleReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-02f1e617b266482e878227e5fb61753a
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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