tert-butyl 5-benzoylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate → HCID 58312740, Verbindung

HRID 75683

Reaktionsgleichung

Reaktionsgleichung von HRID 75683
[C:1]([N:9]1[CH2:13][CH:12]2[CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][CH:11]2[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH2:10]1[CH:11]2[CH2:16][NH:15][CH2:14][CH:12]2[CH2:13][N:9]1[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:8]

Komponenten

4

Edukt 1

HCID 71285668tert-butyl 5-benzoylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Produkt 1

HCID 58312740HCID 58312740, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

tert-butyl 5-benzoylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (100 mg) was dissolved in 10% TFA solution in CH2Cl2 (10 mL). The reaction was stirred at room temperature for 24 hours. After removal of solvents, the residue, (hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(phenyl)methanone, was used in the further reactions without purification.

Aufarbeitung

  1. customAfter removal of solvents
  2. customthe residue, (hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(phenyl)methanone, was used in the further reactions without purification

Quellen und Nachweise

ORD-Eintrag
ord-fe45223192ee436fafefecb4c2ceabd6
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835454B2

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