Formamide → 7-Fluoroquinazolin-4(3H)-one

HRID 75707

Reaktionsgleichung

Reaktionsgleichung von HRID 75707
[NH2:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>CN(C)C=O>[F:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:5])[NH:14][CH:12]=[N:1]2)=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 713FormamideHCID 27249674-Fluoroanthranilic acid

Produkt 1

HCID 1353984967-Fluoroquinazolin-4(3H)-oneAusbeute 81,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
180 °C

Versuchsvorschrift

2-amino-4-fluorobenzoic acid (100 g, 0.64 mol) and formamide (154 mL, 3.87 mol) were mixed with a catalytic amount (1 mL) of N,N-dimethylformamide. The mixture was heated to 180° C. and further stirred for 14 hours. The mixture was cooled to room temperature, and distilled water (1000 mL) was added thereto. The mixture was stirred for 30 min and filtered to obtain the title compound (86 g, 81.3%).

Aufarbeitung

  1. temperatureThe mixture was cooled to room temperature
  2. distillationdistilled water (1000 mL)
  3. additionwas added
  4. stirringThe mixture was stirred for 30 min
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-25bcd9b5e8a44c889d87d8e953462ed9
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835458B2

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