methyl (2S)-2-amino-3-methoxypropanoate hydrochloride → (S)-2-({3-[3-(6-Fluoro-benzothiazol-2-ylamino)-phenyl]-isoxazole-5-carbonyl}-amino)-3-methoxy-propionic acid methyl ester

Beteiligte Stoffe

Reaktionsschritte

The title compound was prepared according to the procedure as set forth in Example 5, except that 3-[3-(6-fluoro-benzothiazol-2-ylamino)-phenyl]-isoxazole-5-carboxylic acid was used instead of the compound of Example 2 and (S)-2-amino-3-methoxy-propionic acid methyl ester hydrochloride was used instead of (S)-Val-OMe.HCl to yield 68% of the title compound. Mass (ES+): 471 (M++1), 493 (M++Na); IR (KBr): 3319, 2929, 1740, 1670, 1571, 1474; 1H NMR (DMSO-d6) δ: 3.29 (s, 3H), 3.67 (s, 3H), 3.74 (m, 2H), 4.74 (m, 1H), 7.18 (m, 1H), 7.53 (m, 2H), 7.62 (dd, 1H), 7.72 (s, 1H), 7.76 (dd, 1H), 7.95 (m, 1H), 8.32 (s, 1H), 9.39 (d, 1H), 10.70 (s, 1H).

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