2-Fluorophenyl isocyanate → HCID 178477460, Verbindung

HRID 75824

Reaktionsgleichung

Reaktionsgleichung von HRID 75824
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[O:10].[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:22]=[C:21](/[C:23](=[N:27]/[C@H:28]([CH:33]([CH3:35])[CH3:34])[C:29]([O:31][CH3:32])=[O:30])/[S:24][CH2:25][CH3:26])[O:20][N:19]=2)=[CH:14][CH:13]=1>>[CH2:25]([S:24]/[C:23](=[N:27]\[C@H:28]([CH:33]([CH3:34])[CH3:35])[C:29]([O:31][CH3:32])=[O:30])/[C:21]1[O:20][N:19]=[C:18]([C:15]2[CH:16]=[CH:17][C:12]([NH:11][C:9]([NH:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])=[O:10])=[CH:13][CH:14]=2)[CH:22]=1)[CH3:26]

Komponenten

3

Edukt 2

HCID 855882-Fluorophenyl isocyanateHCID 178477459HCID 178477459, Verbindung

Produkt 1

HCID 178477460HCID 178477460, VerbindungAusbeute 76 %

Versuchsvorschrift

The title compound was prepared according to the procedure as set forth in example 151, except that 1-fluoro-2-isocyanatobenzene was used in place of 1-fluoro-3-isocyanatobenzene and (R,Z)-methyl 2-((3-(4-aminophenyl)isoxazol-5-yl)(ethylthio) methyleneamino)-3-methylbutanoate was used in place of methyl 2-(3-(4-aminophenyl)isoxazole-5-carboxamido)-3-methylbutanoate to yield 76% of the title compound. MS (ESI): m/z 499 (M+H)+; 1HNMR (DMSO-d6, 300 MHz): δ 8.124 (s, 1H), 8.101 (d, 1H), 7.858 (s, 1H), 7.593 (m, 1H), 7.406 (m, 1H), 7.260 (s, 2H), 7.095 (m, 2H), 6.991 (m, 1H), 6.701(d, 1H), 4.583 (d, 1H), 3.843 (s, 3H), 3.075 (m, 2H), 2.450 (s, 1H), 1.331 (t, 3H), 1.076 (d, 6H).

Aufarbeitung

  1. customThe title compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-d4dcc3bb15a7434f9f018007d732f81a
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835428B2

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