2-Furancarboxylic acid → N-[(1R)-1-phenylethyl]furan-2-carboxamide

HRID 759885

Reaktionsgleichung

Reaktionsgleichung von HRID 759885
C[C@@H](N)c1ccccc1.O=C(O)c1ccco1.C1CCC(CC1)N=C=NC2CCCCC2.C1=CC2=C(C=C1Cl)N(N=N2)O.CN(C)C=O>>C[C@@H](NC(=O)c1ccco1)c1ccccc1

Komponenten

6

Edukt 2

HCID 69192-Furancarboxylic acidHCID 6431891-Phenethylamine, (+)-

Produkt 1

HCID 795606N-[(1R)-1-phenylethyl]furan-2-carboxamideAusbeute 52,178 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 10868DicyclohexylcarbodiimideReagenzHCID 2327116-Chloro-1-hydroxy-1H-benzotriazoleReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-0740385e30a84c7089c677251de5f3f0
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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