Triethylamine → 2-Chloro-n-(5-methyl-1h-pyrazol-3-yl)quinazolin-4-amine

HRID 7601

Reaktionsgleichung

Reaktionsgleichung von HRID 7601
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][C:14]1[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=1.C(N(CC)CC)C>C(O)C>[Cl:1][C:2]1[N:11]=[C:10]([NH:13][C:14]2[NH:15][N:16]=[C:17]([CH3:19])[CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 2528862,4-Dichloroquinazoline

Produkt 1

HCID 219391632-Chloro-n-(5-methyl-1h-pyrazol-3-yl)quinazolin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 2,4-dichloroquinazoline (12.69 g, 63 mmol) and 3-amino-5-methylpyrazole (6.18 g, 63 mmol) in ethanol (220 mL) is added triethylamine (8.13 mL, 63 mmol) and the reaction mixture is stirred for 3 hours at room temperature. The pale yellow precipitate is then collected by filtration, washed with cold ethanol and dried under vacuum to give (2-chloroquinazolin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.

Aufarbeitung

  1. filtrationThe pale yellow precipitate is then collected by filtration
  2. washwashed with cold ethanol
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-40d7272e26be49c1ab66795f224e7323
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087603B2

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