Benzyl Chloride → Methyl 2,3-bis(benzyloxy)benzoate

HRID 76088

Reaktionsgleichung

Reaktionsgleichung von HRID 76088
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[OH:11].[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]=1[O:11][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

3

Edukt 2

HCID 7503Benzyl ChlorideHCID 75484Methyl 2,3-Dihydroxybenzoate

Produkt 1

HCID 10665397Methyl 2,3-bis(benzyloxy)benzoate

Versuchsvorschrift

In one embodiment, the compounds can be prepared as shown in Scheme II. A dihydroxy benzoic acid methyl ester is reacted with benzyl chloride, to produce a Bis-benzyloxy benzoic acid methyl ester (1). The Bis-benzyloxy benzoic acid methyl ester can then be heated with LiOH to give a Bis-benzyloxy benzoic acid (2). The Bis-benzyloxy benzoic acid (2) is then reacted with an aminophenyl to produce a phenyl-benzamide (3). The phenyl-benzamide (3) is then reacted with hydrazine to give a triazol (4). The hydroxy groups can then be unprotected in the presence of palladium on charcoal to give the final product.

Aufarbeitung

  1. customIn one embodiment, the compounds can be prepared

Quellen und Nachweise

ORD-Eintrag
ord-ebfc6169a3ab4ce89cf4bf4ea3f92fa0
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835464B2

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