2-(4-Bromophenyl)propanenitrile → 2-(4-Bromophenyl)propan-1-amine

HRID 76145Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 76145
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:11])[C:9]#[N:10])=[CH:4][CH:3]=1>[Ni].N>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH3:11])[CH2:9][NH2:10])=[CH:6][CH:7]=1

Komponenten

4

Edukt 1

HCID 107509272-(4-Bromophenyl)propanenitrile

Produkt 1

HCID 107986602-(4-Bromophenyl)propan-1-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 222AmmoniaLösungsmittel

Versuchsvorschrift

A mixture of 3.00 g (14.3 mmol) 2-(4-bromo-phenyl)-propionitrile and 40 mL ammonia solution (7N in methanol) is charged with 0.30 g Raney nickel. The mixture is stirred under an atmosphere of hydrogen (50 psi) at r.t. for 34 h. The mixture is filtered and the solvent is removed in vacuo. The crude product is used without further purification.

Aufarbeitung

  1. filtrationThe mixture is filtered
  2. customthe solvent is removed in vacuo
  3. customThe crude product is used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-5ebc63f5e247468e89ccb9bbfd6ddfc8
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835472B2

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