2-Pyrrolidone → 1-(4-Iodobenzyl)pyrrolidin-2-one

HRID 76155

Reaktionsgleichung

Reaktionsgleichung von HRID 76155
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[H-].[Na+].[I:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14]Br)=[CH:12][CH:11]=1>CN(C=O)C>[I:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])=[CH:12][CH:11]=1

Komponenten

5

Edukt 3

HCID 120252-PyrrolidoneHCID 24758Sodium hydrideHCID 9542584-Iodobenzyl bromide

Produkt 1

HCID 509928621-(4-Iodobenzyl)pyrrolidin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To 140 μl (1.68 mmol) 2-pyrrolidone in 5 mL DMF are added 110 mg (2.53 mmol) sodium hydride. Then 500 mg (1.68 mmol) 4-iodobenzyl bromide are added by several portions and the resulting mixture is stirred at r.t. over night. The solvent is removed in vacuo and the residue is resolved in DCM and water. The layers are separated and the organic layer is dried with Na2SO4, filtrated and the solvent is removed in vacuo. The crude product is purified by HPLC.

Aufarbeitung

  1. customThe solvent is removed in vacuo
  2. customThe layers are separated
  3. dry with materialthe organic layer is dried with Na2SO4
  4. filtrationfiltrated
  5. customthe solvent is removed in vacuo
  6. customThe crude product is purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-392c23370f18485ea0366c42b5d658a8
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835472B2

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