N-(1-(4-Iodophenyl)propan-2-YL)acetamide → 4-Iodo-alpha-methylbenzeneethanamine

HRID 76163

Reaktionsgleichung

Reaktionsgleichung von HRID 76163
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:11]C(=O)C)[CH3:10])=[CH:4][CH:3]=1>Cl>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([NH2:11])[CH3:10])=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 66611344N-(1-(4-Iodophenyl)propan-2-YL)acetamide

Produkt 1

HCID 1238704-Iodo-alpha-methylbenzeneethanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

9.00 g (29.69 mmol) N-[2-(4-iodo-phenyl)-1-methyl-ethyl]-acetamide (I52.1) are added to 150 mL HCl (4N) and the reaction mixture is stirred at reflux over night. Then the mixture is diluted with soda lye and extracted with EtOAc. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo.

Aufarbeitung

  1. temperatureat reflux over night
  2. additionThen the mixture is diluted with soda lye
  3. extractionextracted with EtOAc
  4. dry with materialThe organic layer is dried with Na2SO4
  5. customthe solvent is removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6972a19953ff4a0ca677f361275db46a
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835472B2

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