Methanol → Methyl p-aminosalicylate

Reaktionsgleichung

[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

Komponenten

Edukt 2

HCID 887Methanol

HCID 46494-Aminosalicylic Acid

Produkt 1

HCID 77787Methyl p-aminosalicylate

Versuchsvorschrift

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

Aufarbeitung

customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
customThe organic layer was separated
customdried
customevaporated

Quellen und Nachweise

ORD-Eintrag: ord-e159ba31816b4b928b6553cecf01fe6b
Quelldatensatz: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08835430B2

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