Methanol → Methyl p-aminosalicylate

HRID 76646

Reaktionsgleichung

Reaktionsgleichung von HRID 76646
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

Komponenten

3

Edukt 2

HCID 887MethanolHCID 46494-Aminosalicylic Acid

Produkt 1

HCID 77787Methyl p-aminosalicylate

Versuchsvorschrift

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

Aufarbeitung

  1. customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
  2. customThe organic layer was separated
  3. customdried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e159ba31816b4b928b6553cecf01fe6b
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835430B2

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