Ethanol → Ethyl 2-(3-fluorophenyl)acetate

HRID 76966

Reaktionsgleichung

Reaktionsgleichung von HRID 76966
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH2:17](O)[CH3:18]>>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:17][CH3:18])=[O:10])[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 676173-Fluorophenylacetic acid

Produkt 1

HCID 11735538Ethyl 2-(3-fluorophenyl)acetateAusbeute 85 %

Versuchsvorschrift

To a solution of 3-fluorophenyl acetic acid (10.0 g, 64.9 mmol) in ethanol (300 mL), is added a catalytic amount of H2SO4 (98%, 1 mL) and the mixture reacted for 12 hours at 100° C. (LC-MS monitoring: complete conversion). The solvent is evaporated and the residue is partitioned between EtOAc and water; the organic layer is separated and dried over Na2SO4 in order to obtain 10.1 g of (I8) as a white solid (85% yield).

Aufarbeitung

  1. customthe mixture reacted for 12 hours at 100° C. (LC-MS monitoring: complete conversion)
  2. customThe solvent is evaporated
  3. customthe residue is partitioned between EtOAc and water
  4. customthe organic layer is separated
  5. dry with materialdried over Na2SO4 in order

Quellen und Nachweise

ORD-Eintrag
ord-38049ee9739249dfa2ee123b242c4d2b
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835682B2

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