m-Aminoacetanilide → (3-Acetylamino-phenylamino)-phenyl-acetic acid ethyl ester

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

N-(3-Aminophenyl)acetamide (371 mg, 2.47 mmol), ethyl 2-bromo-2-phenylacetate (0.29 mL, 1.64 mmol), and DIPEA (0.43 mL, 2.47 mmol) are dissolved in acetonitrile (5 mL). The reaction is heated under MW irradiation at 100° C. for 30 minutes. Conversion complete by UPLC/MS-UV. Acetonitrile is evaporated and the crude residue is purified by flash chromatography (DCM/EtOAc=8/2) to obtain intermediate I92 as a colorless oil (440 mg, 86% yield).

Herkunft & Nachweise